030 – Natural Support for Heartburn and Stomach Distress- Interview with Dan Murray

Pepzin GI is a unique supplement for irritated stomach lining.

Dan MurrayMany people suffer with stomach problems. There are numerous digestive issues and many different natural ways to address those issues. Most visitors to this podcast will know about digestive enzymes and probiotics. Those are important supplements. In this interview with Dan Murray, you will learn about a unique supplement for your stomach, that is unlike any other.

Pepzin GI is the trademarked name for zinc-carnosine. Zinc-carnosine has been used in Japan as a pharmaceutical product since 1994. In the U.S. it is sold as Pepzin GI. Pepzin GI has dozens or research studies and more than 12 years of human experience.

Pepzin GI supports the mucosal lining of the stomach and GI track. This mucosal lining is the body’s natural defense against the strong stomach acid. Current medical practice is to prescribe acid blocking drugs to relieve symptoms. This has several negative consequences. It does not fix the problem. Drugs will provide relief but you are no closer to a solution for the problem. Many others who regularly use pain medicine such as aspirin, ibuprofen or prescription pain relievers have stomach irritation as a common side effect.

Pepzin GI helps to support the natural mucosal lining. It can provide wonderful relief for occasional heartburn, acid indigestion, gas and nausea. A healthy mucosal lining can inhibit harmful bacteria associated with stomach irritation. Pepzin GI has potent tissue healing properties. If you have stomach issues related to irritation or ulcers, you should try Pepzin GI. I don’t know of anything else like it, that has these unique properties.

One study showed that heartburn was improved by 85% in only 14 days and was gone completely in over 60% of the participants. For more information go to PepzinGI.com.

Dan Murray is the VP of Business Development at Xsto Solutions. Xsto’s main focus is to bring science supported nutritional ingredients to U.S such as Pepzin GI and NiaXtend.

Support for this podcast episode is provided by


{ 41 comments… read them below or add one }

1 Constance May 8, 2019 at 10:51 am

This is a great product I have had issues for 4 years Started taking one before breakfast and one before dinner. Issue resolved. Nothing else worked.


2 Steve Lankford May 8, 2019 at 11:24 am

Thank you for sharing your experience.


3 dina fikremariam February 10, 2019 at 5:34 pm

can i open the capsule and mix it with water?


4 Steve Lankford February 10, 2019 at 5:39 pm

Probably. Capsules break down very quickly in the stomach. To be sure, contact the company and ask them as I don’t know definitively.


5 Leah January 5, 2019 at 7:30 pm

My husband has severe acid problems but does not want to go to a doctor. His mother and brothers also suffer from the same issues. He can’t hardly eat anything without throwing it up later if he hasn’t taken his omeprazole magnesium. The omeprazole seems to work just fine for him, however I am concerned about the long term effects that it may have. He also suffers from severe heartburn and gas issues. There have been times when he has skipped his omeprazole for about a week or so and begins to vomit again (sometimes dark, almost black vomit). If he does not eat he is fine, but no matter how conscious he is of what he consumes the problem still persists, so I know that it stems from having any type of food intake whatsoever. Do you think that this product would be a good solution for him? Or would it even be worth trying? Do you know if it could possibly cause any harm?


6 Steve Lankford January 6, 2019 at 3:40 pm

This product may help, but it sounds like he will need more than just that. I suggest you seek out a nutritional practitioner in your area. If you can’t find one contact PERQUE.com and they can refer you to nutritional specialists. Good luck.


7 Chris Verstijnen December 16, 2018 at 5:04 pm

Hi Steve, can you take Pepzin GI with a probiotic?


8 Steve Lankford December 17, 2018 at 9:53 am

I don’t know of any reason why not. Follow label directions. You could also contact both companies and see if they have any guidance.


9 sean October 10, 2018 at 11:50 pm

Hi Steve

I’ve been using pepzin gi for the past 2 years with a dosage of 2 tablets daily and its been quite effective for my acidity. I was recently diagnosed with a tiny non benign tumor in my urinary bladder and got it removed. Want to know if this was a long term effect of using pepsin gi please advise. Thanks


10 Steve Lankford October 11, 2018 at 8:13 am

I don’t know of any connection.


11 Elliot Gonzales July 4, 2018 at 4:32 pm

Hello there! I don’t have pain in my stomach but I have had this feeling or discomfort in there for a while. I never had any issues in my 38 years but when I began treating my gallbladder sludge issue with supplements I began to feel that stomach discomfort I talk about. I attribute my feeling better to PepZin GI, I am using this brand https://www.protocolforlife.com/gi-guard-am/, but I am unsure if I can take it for a long time or if I should up the dose. I would also love to know if I can combine it with DGL licorice.


12 Steve Lankford July 4, 2018 at 4:45 pm

You can take Pepzin GI ongoing. You can also experiment with the dose. You should also be able to take it with DGL.

You could consider digestive enzymes, especially lipase for fats.

Good luck and best wishes.


13 tammy johnson April 20, 2018 at 9:54 pm

does Pepzin GI help heal ulcers an repair stomach lining ???


14 Steve Lankford April 21, 2018 at 8:40 am

It would be useful as part of a comprehensive program.


15 Marisa January 10, 2018 at 11:48 am

I was diagnosed with gastritis and have recently started using PepZinGI for treatment. If I am also taking DGL before each meal, to be most effective should I be taking the PepZinGI before or after my dose of DGL?


16 Steve Lankford January 10, 2018 at 11:55 am

I would follow the label directions on each product. They work differently and my guess is that they are compatible.


17 Ellena Nortje July 18, 2017 at 3:19 pm

Does one take Pepzin GI between meals on an empty stomach or with food? Can it be taken eith medication like Zantac?


18 Steve Lankford July 18, 2017 at 4:18 pm

Follow label directions. It should be OK with Zantac as far as I know. You could research that further. Try to contact the manufacturer and ask them.


19 Joanna October 29, 2016 at 6:19 pm

I am a 51 y/o woman who had arthroscopic rotator cuff surgery ~3 weeks ago. The surgeon reported having found excessive inflammation, and prescribed a 15 day course of prednisone followed by 30 days naproxen. I have developed stomach pain with NSAIDs in the past, and as I suspected I would, I had stomach pain the first day of naproxin, despite taking omeprazole & eating prior to taking it. I haven’t taken the naproxin for two days, and am taking two omeprazoles -AM & PM-hoping I can heal the lining & then resume naproxin. Would your product help? Please advise. I’m worried about thie inflammation, but don’t want a bleeding ulcer. Thanks.


20 Steve Lankford October 30, 2016 at 8:50 am

I would recommend a therapeutic dose of omega-3 to help reduce chronic inflammation. Curcumin extracts can mitigate pain. PepzinGI can help protect the stomach lining. Digestive Enzymes designed for over acid stomach can be very helpful.

FYI: This is not our product. We do not sell products or link to selling sites. I recommend you visit an independent health food store where the owners know about good nutrition.

Good luck and best wishes.


21 Mark September 8, 2016 at 6:05 am

Hi, I used pepzin gi in 1st june for the first time. I felt burning sensation in my tummy then. So I stopped it and kept it at dry place. But I want to use it again now.
I realize that it has been 3 month now. Could I use it again(the bottle has already opened). Or I should buy another one?


22 Steve Lankford September 8, 2016 at 8:05 am

It should be fine to use. Good luck.


23 sean August 9, 2016 at 7:38 am

Hi Steve sorry to bother you again!! Like I said earlier ive been off ppi and now using pepzin gi for the past 8 months and its been great!! Lately ive been suffering from dry throat and irritation so I went to an ENT Dr and after examining he said I’m suffering from acid reflux and that I should take ppi for 2 weeks. Need your opinion


24 Steve Lankford August 9, 2016 at 3:06 pm

Two weeks is an appropriate time frame for a ppi. It may help calm down the irritation. See if it helps. I would consider other options if it goes beyond two weeks. Good luck.


25 sean wu July 13, 2016 at 12:18 am

Hi Steve

I’ve been on Dr Best pepzin gi for the past 6 months and it has totally replaced my ppi medication. Should I stop taking it or continue. Please advise . THanks


26 Steve Lankford July 13, 2016 at 8:47 am

You can keep taking it as it is helping you. You can try to taper down and see what happens. If you taper down to none and stay good, then it would seem OK to stop. You may find that going down on dose eventually leads to a recurrence then go back to the effective dose.


27 SEAN July 26, 2016 at 12:36 am

Thank you Steve!! What you said exactly happened once I reduced my dose to one tablet a day I felt slight acidity sometimes. but is it safe to keep taking pepzin gi because it works very well!!


28 Steve Lankford July 26, 2016 at 8:23 am

I know of no reason why you can’t continue on PepzinGI at the dose that works best for you. Good luck and best wishes.


29 SEAN July 28, 2016 at 1:11 am

Thank You Steve!!

30 Jonathan Porter May 13, 2016 at 9:30 am

I am on my second bottle of Pepzin GI. It helps, but it definitely doesn’t get rid of my heartburn and gastritis, despite my bland (and boring) diet. I am taking, slippery elm, dgl, a probiotic and Monolaurin, so I am hoping it will continue to get better.


31 Steve Lankford May 13, 2016 at 11:05 am

Look into a product called Heartburn Free by Enzymatic Therapy. https://www.enzymatictherapy.com/Products/Digestion/Occasional-Heartburn-and-Indigestion/09110-Heartburn-Freewith-ROH10.aspx

There is also Acid Soothe by Enzymedica. http://enzymedica.com/products/acid-soothe-heartburn-all-natural

You will likely need a variety of tools to get the best overall results. Nutrients like aloe vera juice and peppermint could be useful. Anti-acid supplements can neutralize acidity in the moment for quick relief. Keep on the Pepzin GI and add others one at a time to evaluate their benefits. Good luck.


32 Joe August 10, 2022 at 9:31 am

Does this help for LPR?


33 S L August 31, 2022 at 2:59 pm

I don’t know. It might. It should not be a problem to try it and see.


34 Christopher Tishlias June 18, 2016 at 7:33 pm

Hey Johnathon,

I’d like to hear how your doing as I’m basically taking the same supplements as you are with a similar issue of either severe gerd or gastritis with a possible hiatal hernia. Will be getting an endoscopy in 2 weeks, but would love to get some feedback on how things are going….I know how bad the chest pain heartburn is


35 Jane December 14, 2014 at 2:55 am

Can Pepzin GI be taken with a probiotic in the morning? Should the probiotic be taken with the meal and Pepzin GI after the meal?


36 Steve Lankford March 11, 2015 at 5:21 pm

As far as I know, you should be able to take them at the same time.


37 carla kennedy September 22, 2014 at 5:31 am


I was diagnosed with H Pylori which since treatment (2drugs and anti acid) a second test proved negative. Although I’m much better I still get some pain albeit usually mild but still not nice, and I’m waiting for the result of a barium meal
Would these tabs help? At the moment I’m taking Liquorice DLG 1-2 twice daily which don’t seem to be helping and I ‘ve also tried loads of other natural product , but not the above.
If indeed I have low stomach acid (many years ago I was told I had after 24hrs test) and don’t get heartburn but could they still help with the mild stomach pain?
Kind regards Carla


38 Steve Lankford March 11, 2015 at 5:23 pm

It is possible that Pepzin GI could help you. The only way to know is to try. There is another product by Enzymatic Therapy called Heartburn Free that may help. Good luck.


39 Lori Pendergraft September 14, 2014 at 11:27 am

I have ordered a bottle of Pepzin Gi and I’m sure it will help with my gastritis but I haven’t read or see anywhere on how long to stay on your acid reducer pills while taking the Pepzin? I would like to know how long I need to keep taking the acid reducer pills and also how long I keep taking the Pepzin?

Thank you ahead of time for your quick response.


40 Steve Lankford September 15, 2014 at 11:00 am

I am not your doctor so this is only my suggestion. After a week on Pepzin GI, try gradually reducing your dosage of the acid blocker. Cut it down by a third and see how you do. If that seems ok then try reducing by another third. If all goes well the try going without.
You could also do other things as well as the Pepzin GI. Take digestive enzymes with your meals. Try Aloe Vera juice (get a good one, not a cheap one, like Aloe Life.)
Also watch your foods and see if some are more bothersome.
You could try smaller meals more often.
These are just a few other lifestyle ideas that may help as well. Good Luck and best wishes.


41 Steve Lankford May 2, 2013 at 7:30 am

Thank you for your kind words. It is my honor to be recommended to your friends and social networks.


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