396 – Phosphatidyl Serine for Dementia and Cognitive Decline

Maintain and improve mental performance — memory, learning, concentration, focus, recall.

This podcast from the past is one of our best.

Phosphatidyl Serine (PS) can play a critical role in both maintaining and improving mental performance – name and face recognition, recalling locations of misplaced objects, concentration, and focus – which is often an unfortunate component of the normal aging process. A multitude of scientific studies have shown that SerinAid PS can significantly help maintain and improve mental performance, can help improve mood, and can make a valuable contribution to lowering both physical and psychological stress.

FDA Approved Qualified Claim


Recognizing how effective PS really is, the US Food and Drug Administration (FDA), in February, 2003, granted two significant health claims for PS, indicating that PS may reduce the risk of cognitive dysfunction and dementia in the elderly.

Health Benefits

Improvement in key brain functions, including memory, concentration, learning, recall, and focus.

SerinAid Phosphatydl Serine
  • Prevention of memory loss, especially age-related cognitive decline.
  • Reduction of elevated cortisol levels and reduction of stress.
  • Improvement in athletic activities including running, weightlifting, and golf.
  • Helps reduce fatigue, reduces muscle soreness, and hastens recovery, in active and athletic individuals.

Exploring the Science

Currently there are about 179,000 citations for Phosphatidyl Serine on Google Scholar. Over 8000 studies in 2021,

SerinAid® PS assists proteins that manage membrane functions, assists the entry of nutrients into cells and the exit of harmful, stress-related waste products out of cells, and is involved in transmission of molecular messages from cell to cell. Collectively, although the results of PS supplementation in children have not been conclusive, many physicians and holistic practitioners, believe that PS can help children and young adults with their behavior disorders and also with their mood and stress related challenges.

Statin Drugs

It is widely known that the use of statins (cholesterol lowering drugs) can severely impact on skills involving brain function. It is estimated that approximately 20 million Americans already use statins, and that this number might double if the cholesterol standards are actually lowered, as more people are prescribed statins.

Studies have shown that after six months of statin use, patients performed poorly in tests involving complex mazes, psychomotor, and memory tests. In addition, recently published studies have indicated that in addition, obese individuals often suffer from memory loss and other cognitive impairments. Again, PS has become a widely used safe nutrient to support mental performance under these circumstances.

Elevated Cortisol

Elevated levels of cortisol, a catabolic stress hormone released by the body when a person is subjected to physical and emotional stress, can ravage both muscle tissue and brain cells, thus impairing optimal cellular activity. With regular dietary supplementation using SerinAid PS, elevated cortisol levels can be safely reduced, and both cognition and immune system functions can be optimized.

Current research has been conducted in assessing how PS might act as a true ergogenic agent in improving exercise performance. A number of recently published findings have shown that PS can significantly help exercising individuals improve exercise capacity, reduce muscle soreness, reduce fatigue, and hasten recovery. Finally, PS has been shown in a published research study to aid golfers in their ability to accurately drive a golf ball and to reduce their stress levels.

Safe and Effective

PS is a proven, efficacious, natural, and extremely well tolerated nutrient, and of course, it is safe to use every day. That is why PS has become such a highly recognized and highly respected mental performance supplement.

PS is extremely well documented, and has been researched in more than 40 human clinical trials over a period of more than 30 years in research studies throughout the world. More than 20 placebo controlled clinical trials have consistently proven that PS has considerable value as a dietary supplement, and that the normal diet provides an insufficient amount of PS.

Scott Hagerman

Scott Hagerman

As President & CEO (now retired) of both Chemi Nutra and Chemi Pharma, Scott Hagerman draws on over 30 years of relevant experience in the nutritional supplement, food, and pharmaceutical industries. His experience in nutrition science research includes a BS Degree in Food Science & Human Nutrition from the University of Minnesota, Minneapolis, MN, an MBA Degree in Marketing & Finance from Keller Graduate School of Management, Chicago, IL, and Certified Strength and Conditioning Specialist (CSCS) accredited certification with the National Strength and Conditioning Association. Scott is personally committed to the practice of healthy nutrition and physical fitness, and serves as a strong ambassador to the nutritional supplement, functional food, and sports nutrition industries.

Chemi Nutra

Founded in 2001 under our Italian parent company, Chemi S.p.A., Chemi Nutra is a US-based bulk nutraceutical (dietary ingredient) company. Widely regarded as a pioneer in the nutrition industry and are best known for introducing phosphatidylserine (PS) and alpha-glyceryl phosphoryl choline (Alpha-GPC) into the North American market.

Chemi Nutra

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